Found in Translation 2016

Found in Translation 2016
Patient samples in phenotypic
assays, target and biomarker discovery
/zagreb, october 13-14, 2016

The Meeting venue is BIOCentre, Borongajska cesta 83h, Zagreb, Croatia

Studies using human tissue for identification and validation of novel targets, for setting up ex vivo testing systems and biomarker discovery are being performed more frequently in both academic and industry research. In addition, numerous random attempts have been made to use human material to improve drug discovery paradigms that are currently being incorporated into the novel strategies.

The intention of the FIT 2016 meeting is to bring together various individuals who use patient samples as an integral part of their work (basic and drug discovery scientists, clinicians, as well as legal/regulatory representatives) and to exchange their experiences of best practices, success stories and disappointments.

The meeting is organized jointly by Fidelta, BIOCentre and Ruđer Bošković Institute in collaboration with The Croatian Society for Mucosal Immunology of the Croatian Medical Association.

PLEASE COME AND SHARE YOUR VIEWS, DILLEMAS AND IDEAS

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Meeting Overview

Day 1

Setting the Scene

  • Talks
  • Posters

Day 2

“Unconferencing” – participant driven meeting

(take a lead – post a topic or question)

  • Group discussions – topics proposed by attendees
  • Show and tell – great project or something to show
  • My big (or little) question – the question you want to know answer to

Programme

Three thematic sessions (lectures, posters and discussion workshops):

  • Patient samples in drug discovery
    • Overview of the field and general principles
    • Legal aspects and EU rules and regulations
    • Presentations on successful and less successful real life examples
  • Target and biomarker identification and validation
    • Various state of the art techniques and technologies used for target and biomarker discovery and validation (e.g. chemoproteomics, CRISPR, etc.) – with special accent on case studies
  • Compound profiling in phenotypic assays
    • Cell lines vs. primary cells vs. co-cultures vs. tissue explants

 

DAY 1

8.30-9.00 Registration
9.00-9.15 Opening and Wellcome notes
Dubravko Kičić, BIOCentre
Phil Dudfield, Fidelta
Tome Antičić, Ruđer Bošković Institute
Chair: Martina Bosnar and Dubravko Jelić
9.15-9.45 Vesna Eraković Haber Setting the stage - patient samples and drug discovery
9:45-10:15 Michael J. Parnham Predictive translational biomarkers for the disease
10:15-10:45 Andy Blanchard Enhancing drug discovery in fibrosis using Laser Capture Microdissection (LCM) and Precision Cut Lung Slices (PCLS)
10.45-11.15 Coffee Break sponsored by Diagnostica Skalpeli
11:15-11:45 Maarten Gees Use of patient- derived primary cells for finding new CFTR modulators in CF
11:45-12:15 Bart DeCorte The power of phenotypic screening in the exploration of the biological potential of novel chemical space
12.15-13.15 Lunch
Chair: Sanja Šale and Mario Cindrić
13:15-13:45 Jasna Križ In vivo imaging technologies and cell type specific proteomics for target validation in preclinical studies
13:45-14:15 David Goodlett Review of the use of biobanked serum samples to distinguish children developing Type-1 Diabetes
14:15-14:45 Graham Dixon Developing a biomarker tool kit to facilitate the clinical development of AsiDNA, a first in class DNA repair inhibitor
14:45-15:15 Coffee Break sponsored by Diagnostica Skalpeli
15:15–15:45 Fran Borovečki Use of patient samples in discovery of novel biomarkers - a clinician's perspective
15:45-16:15 Ana Borovečki Ethical and legal regulations of use of patient samples in drug discovery research
16:15-17:30 Wine & Cheese Poster Session sponsored by AlphaChrom
Maruška Marušić and Ivona Kaselj Complete Solution For Automated Imaging and High Content Screening

DAY 2

9:00-12:30 Discussions on various topics
Chairs: Vesna Eraković, Amela Hozić and Dubravko Kičić
   - Imaging
Gorana Aralica and Ivica Kopriva New methods for segmentation and enhancement of hystopathological images
   - Novel technologies
Srećko Gajović Stem cells as a valuable tool in preclinical biomedical research
Branimir Gizdić CRISPR/Cas9 technology – principles and applications
   - Phenotypic vs. target based drug discovery
12.30-13.30 Lunch
13.30 Guided lab tours

Speakers


  • Vesna Eraković Haber

    Fidelta d.o.o., Croatia
    Setting the scene - patient samples in drug discovery
  • Michael J. Parnham

    Goethe University and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Frankfurt am Main, Germany
    Predictive translational biomarkers for the disease
    • Andy Blanchard

      GlaxoSmithKline, UK
      Enhancing drug discovery in fibrosis using Laser Capture Microdissection (LCM) and Precision Cut Lung Slices (PCLS)
    • Maarten Gees

      Galapagos NV, Belgium
      Use of patient-derived primary cells for finding new CFTR modulators in CF
    • Bart DeCorte

      Janssen Pharmaceutical Companies of Johnson & Johnson (retired) and Kodib, LLC, USA
      The power of phenotypic screening in the exploration of the biological potential of novel chemical space
    • Fran Borovečki

      School of Medicine, University of Zagreb and University Hospital Centre Zagreb, Croatia
      Use of patient samples in discovery of novel biomarkers - a clinician's perspective
    • David Goodlett

      University of Maryland, Baltimore, Maryland, USA and University of Turku, Finland
      Review of the use of Biobanked Serum Samples to Distinguish Children Developing Type-1 Diabetes
    • Graham Dixon

      Onxeo, France
      Developing a biomarker tool kit to facilitate the clinical development of AsiDNA, a first in class DNA repair inhibitor
    • Jasna Križ

      Laval Medical School, Canada
      In vivo imaging technologies and cell type specific proteomics for target validation in preclinical studies
    • Ana Borovečki

      School of Medicine, University of Zagreb, Croatia
      Ethical and legal regulations of use of patient samples in drug discovery research
    • Gorana Aralica (1) and Ivica Kopriva (2)

      (1) School of Medicine, University of Zagreb and Clinical Hospital Dubrava, Zagreb, Croatia; (2) Instutut "Ruđer Bošković", Zagreb; Croatia
      New methods for segmentation and enhancement of hystopathological images
    • Srećko Gajović

      School of Medicine, University of Zagreb
      Stem cells as a valuable tool in preclinical biomedical research
    • Branimir Gizdić

      BIOCentre, Croatia
      CRISPR/Cas9 technology – principles and applications

Abstract submission

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Submit abstract

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Organising and Programme Committee

President

Vesna Eraković Haber, MD, PhD
Senior Director, Head of Translational Research and Alliances
Fidelta d.o. o.
Prilaz baruna Filipovića 29
Zagreb, HR-10000, Croatia

T:+385.1.888.63.20
F:+385.1.888.64.38
M:+385.98.459.867
vesna.erakovichaber@glpg.com
www.fidelta.eu


Members

Dubravko Jelić, PhD
Group Leader
Fidelta Ltd.
Prilaz baruna Filipovića 29
Zagreb, HR-10000, Croatia

T: +385 1 888 6333
M: +385 91 393 3657
dubravko.jelic@glpg.com
www.fidelta.eu
Martina Bosnar, PhD
Director, In vitro pharmacology
Fidelta d.o.o.
Prilaz baruna Filipovica 29
HR-10000 Zagreb

T: +385 1 8886319
M: +385 91 4351 007
martina.bosnar@glpg.com
Mario Cindrić, PhD
Head, Laboratory for System Biomedicine and Centre for Proteomics and Mass Spectrometry
Ruđer Bošković Institute
Planinska 1, 10 000 Zagreb

T: +385 1 2352 676
M: +385 1 4561 010
mcindric@irb.hr
Amela Hozić, PhD
Senior professional associate
Laboratory for System Biomedicine and Centre for Proteomics and Mass Spectrometry
Ruđer Bošković Institute
Planinska 1, 10 000 Zagreb

T: +385 1 2352 673
M: +385 91 5800 730
amela.hozic@irb.hr
Dubravko Kičić, PhD, EMBA
CEO, President of the Bord
BICRO BIOCentre Ltd.
Biosciences Technology Commercialization and Incubation Centre
Borongajska 83H, 10000 Zagreb, CROATIA

dubravko.kicic@biocentre.hr
www.biocentre.hr
Sanja Šale, MD, PhD
CSO, Member of the Board
BICRO BIOCentre Ltd.
Biosciences Technology Commercialization and Incubation Centre
Borongajska 83H, 10000 Zagreb, CROATIA

sanja.sale@biocentre.hr
www.biocentre.hr


 
Hrvatsko društvo za imunologiju sluznice
 



Sponsors


 
 
 
 
 
 


Registration

Registration fee, Early bird 180 EUR (deadline early bird registration, Sep 13th)
Registration fee 220 EUR (late, up to Oct 13th)

Register

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